promethazine and daridorexant the two maximize sedation. Modify Therapy/Keep track of Closely. Coadministration increases hazard of CNS depression, which can result in additive impairment of psychomotor overall performance and cause daytime impairment.Benzodiazepines include drugs like alprazolam, diazepam, and lorazepam. Benzodiazepines could be e